Carcinogenesis In a very life span carcinogenicity research carried out in B6C3F1 mice, methylphenidate prompted a rise in hepatocellular adenomas, and in males only, an increase in hepatoblastomas at a day-to-day dose of approximately 60 mg/kg/day. This dose is around 2 moments the MRHD of 60 mg/day specified to little ones on mg/m2 foundation.For